BK Virus-Specific Antibodies and BKV DNA in Renal Transplant Recipients with BKV Nephritis
نویسندگان
چکیده
منابع مشابه
Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients.
BK virus-allograft nephropathy (BKVAN) is an increasingly recognized complication after kidney transplantation. Quantitative tests have been advocated to monitor patients, but data demonstrating their efficacy are relatively limited. We developed a real-time PCR assay to quantitate BK virus loads in the setting of renal transplantation, and we correlated the BK virus load with clinical course a...
متن کاملBKV replication and cellular immune responses in renal transplant recipients.
Hammer and colleagues report on BKV-specific T-cell responses in peripheral blood mononuclear cells (PBMC) of 15 viremic kidney transplant recipients (1). After stimulation with overlapping peptides spanning the viral capsid protein VP1, interferon-c (IFNc )-producing CD4+ T cells were observed in 7 patients (47%), including 2 patients (13%) with a CD8+ T-cell response. All patients with a dete...
متن کاملBKV QPCR detection and infection monitoring in renal transplant recipients.
BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this stu...
متن کاملProspective study of BKV nephropathy in 117 renal transplant recipients.
Nephropathy caused by poliomavirus (BKVAN) in transplant recipients is responsible for the loss of the transplanted organ. In this study we suggest a non-invasive diagnostic protocol for the early identification of BKVAN during follow-up treatments. In 117 kidney transplant recipients follow-up was performed every three months during a two year period after transplantation and a positive screen...
متن کاملبررسی مولکولی فعالیت مجدد ویروس BK در ادرار بیماران پیوند کلیه
Background & Amis: BK polyomavirus (BKV) is common infection of childhood that persists in kidney epithelium. BKV reactivation characterized by viruria occurs in 35% to 57% of renal allograft recipients. BK virus was detected in serum samples in 6% to 29% of these patients. BKV-associated nephropathy occurs in as many as 8% of renal allograft recipients and may lead to . This study was carri...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2005
ISSN: 1600-6135,1600-6143
DOI: 10.1111/j.1600-6143.2005.01080.x